Oncogenic Viruses and their Tumours

Oncogenic viruses: DUBbing their way to cancer

Ubiquitination is one of the most important post-translational modifications of proteins with a profound effect on their intracellular stability and activity. Deubiquitinases (DUBs), on the other hand, act by removing the ubiquitin moiety from proteins and thereby reverse their stability and/or activity. Besides, DUBs play a major role in maintenance of free ubiquitin pool, histone modification...

Oncogenic Viruses

Oncogenic viruses and hepatocellular carcinoma.

About 80% of hepatocellular carcinoma (HCC) is caused by hepatitis B virus (HBV) and/or hepatitis C virus (HCV) infections especially in the setting of established cirrhosis or advanced fibrosis, making HCC prevention a major goal of antiviral therapy. HCC tumors are highly complex and heterogeneous resulting from the aberrant function of multiple molecular pathways. The roles of HCV or HBV in ...

The Biology of Oncogenic Viruses

New approaches are explored for historians, by 19 eminent writers, in 21 chapters of timely information. The historiography of ideas in medicine, as one aspect, notes that the historian of science is concerned with the thoughts that refer to facts and theories, be they true or not; whereas the scientist is concerned with facts and theories, asking whether they are true or not. Most of the metho...

Human oncogenic viruses: nature and discovery.

Seven kinds of virus collectively comprise an important cause of cancer, particularly in less developed countries and for people with damaged immune systems. Discovered over the past 54 years, most of these viruses are common infections of humankind for which malignancy is a rare consequence. Various cofactors affect the complex interaction between virus and host and the likelihood of cancer em...